proteolüütilised ensüümid, mis osalevad apoptoosis
Caspases are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.
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Nende katalüütilises tsentris on oluline aminohappejääk tsüsteiin ning nad lõikavad märklaudvalgu aminohappeahelat aspartaadijäägi järel. Kaspaasid toodetakse inaktiivsete eellasvalkudena - prokaspaasidena, ning need aktiveeritakse vastusena apoptoosi indutseerivatele signaalidele.
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