Toiduga kokkupuutuvad külmutusained peavad olema piisavalt inertsed ning nendest ei tohi migreeruda toidule koostisosi sellises koguses, mis võiks ohustada inimese tervist, saastata toitu või halvendada selle omadusi.
Whereas it is desirable to provide for the possibility of using cryogenic fluids in direct contact with quick-frozen foodstuffs: whereas therefore these fluids must be sufficiently inert not to impart to the foodstuffs any constituents in quantities liable to constitute a hazard to human health, or to give rise to an unacceptable change in the composition of foodstuffs ...