Loengumaterjal „Võimalikud keemilised terviseohud piimas ja piimatoodetes“. T. Püssa [...] Miks on siis melamiini ja tsüanuurhappe sisaldusel toiduainetes nii madal piirnorm? Selle aluseks on melamiini ja sugulasühendite ühine krooniline toksilisus, mis avaldub ennekõike ja peamiselt neerudes.
Chronic toxicity represents cumulative damage to specific organ systems and takes many months or years to become a recognizable clinical disease. Damage due to subclinical individual exposures may go unnoticed. With repeated exposures or long-term continual exposure, the damage from these subclinical exposures slowly builds-up (cumulative damage) until the damage exceeds the threshold for chronic toxicity. Ultimately, the damage becomes so severe that the organ can no longer function normally and a variety of chronic toxic effects may result.
