need valgud sisaldavad nii N-terminaalset signaaljärjestust, mis suunab nad tsütoplasmavõrgustiku membraani kui ka ülekande peatamise ja ankurdamise järjestust, mis on umbes 22 aminohappest koosnev membraanis asuv hüdrofoobne α-heeliks, Type I transmembrane proteins are anchored to the lipid membrane with a stop-transfer anchor sequence and have their N-terminal domains targeted to the ER lumen during synthesis (and the extracellular space, if mature forms are located on plasmalemma).