It is a gene that represses cancer formation. When this gene mutates to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.
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Kui see geen inaktiveerub (mutatsiooni või alalekspressiooni tõttu), siis võib rakk muutuda (tavaliselt kombinatsioonis teiste geneetiliste muutustega) kasvajarakuks.
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