neli valkude kompleksi (ESCRT-0, ESCRT-1, ESCRT-2 ja ESCRT-3), mis toimivad üksteise järel, et juhtida endosoomi membraanis paiknevaid monoubikvitinüleeritud valke endosoomi valendikusisestesse vesiikulitesse, The endosomal sorting complexes required for transport (ESCRT) machinery is made up of cytosolic protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II, and ESCRT-III. Together with a number of accessory proteins, these ESCRT complexes enable membranes bending/budding away from the cytoplasm.