en

quinupristin

1

Terminological databases

EKI terminibaas Esterm

ID 707786 Last modified 30.12.2004
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Domain ChemistryMedicine - Pathology - Surgery
  • The main component of quinupristin (>88.0%) has the following chemical name: N-((6R,9S,10R,13S,15aS,18R,22S,24aS)-22-(p-(dimethylamino)benzyl)-6-ethyldocosahydro- 10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyl-18-(((3S)-3-quinuclidinylthio)methyl)- 12H-pyrido(2,1-¦)pyrrolo-(2,1-l)(1,4,7,10,13,16) oxapentaazacyclononadecin-9-yl)-3-hydroxypicolinamide.
quinupristin
Usage examples
  • Two streptogramins are clinically important in human medicine in the treatment of last resort of vancomycin resistant enterococci, namely pristinamycin and the combination dalfopristin/quinupristin. ... The risk of reducing the effectiveness of human medicinal products such as erythromycin in particular and possibly lincomycin, clindamycin, pristinamycin and the new combination dalfopristin/quinupristin, which is due to be authorised as a human medicinal product shortly, as a result of selection of cross-resistance caused by tylosin phosphate and spiramycin, should be avoided. ... SCAN notes in its opinion that the virginiamycin-resistant enterococci and staphylococci isolated from poultry and pigs all had cross-resistance to pristinamycin used in human medicine or the combination dalfopristin/quinupristin, which is due to be authorised as a human medicinal product shortly.
  • Synercid® (quinupristin and dalfopristin powder for injection) I.V., a streptogramin antibacterial agent for intravenous administration, is a sterile lyophilized formulation of two semisynthetic pristinamycin derivatives, quinupristin (derived from pristinamycin I) and dalfopristin (derived from pristinamycin IIA) in the ratio of 30:70 (w/w).

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