organophilic - pertaining to a material that associates with organic and oily surfaces and liquids and rejects aqueous systems. An example of organophilic behavior in drilling fluids is the organophilic coating applied to clays and lignites to make them dispersible in oil-base muds., organophilic - of, relating to, or having a strong affinity for organic compounds - used esp. of colloids that swell and form solvates in organic liquids commonly used as solvents