katse, kus tiinele emashiirele süstitakse uuritavat ainet ning aine mutageensust hinnatakse somaatiliste mutatsioonidega neis geenides, mis muudavad karvavärvust: hiirepoegadel on liiniomase karvavärvuse foonil teist värvi täpp või täpid
in vivo test in mice in which developing embryos are exposed to the chemicals
If either of the in vitro gene mutation tests are positive, are in vivo test to investigate unscheduled DNA synthesis or a mouse spot test must be conducted.
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