teatud bakterite poolt toodetav ensüüm, mis lõhustab penitsilliine ja tsefalosporiine ning mille abil bakterid blokeerivad penitsilliini ja tsefalosporiini rea antibiootikumide toimet
any of various bacterial enzymes that inactivate beta-lactam antibiotics (such as penicillin and cephalosporin) by hydrolyzing them
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Vt ka kitsam mõiste „penicillinase - penitsillinaas“. [13.02.2017]
Beta-lactamase was originally used only to refer to bacterial enzymes that inactivated penicillin. As additional types of beta-lactam antibiotics were introduced, other bacterial beta-lactamases were identified.
All penicillins are readily inactivated by chemical or enzymic hydrolysis of the strained four‐membered β‐lactam ring, cold dilute acid yielding penicillamine, and alkali or penicillinases and other β‐lactamases forming the corresponding substituted penicilloic acids.
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