Optoodid võivad omada erinevaid optilisi mõõteskeeme, nagu peegeldumine, neeldumine, evanestsentslaine, luminestsents (fluorestsents ja fosforestsents), kemoluminestsents, pinna plasmoni resonants ja nendest kõige populaarsem metoodika on luminestsents.
Optodes can apply various optical measurement schemes such as reflection, absorption, evanescent wave, luminescence (fluorescence and phosphorescences), chemiluminescence, surface plasmon resonance. By far the most popular methodology is luminescence.
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