et elite controller 1
a patient characterized by undetectable plasma viral loads for extended periods of time in the absence of ART, a subset of HIV-infected individuals who maintain plasma viral loads to levels below the limits of clinical detection (<50–75copies/ml) in the absence of anti-retroviral therapy, sujet non progresseur à long terme et séropositif non traité aux antirétroviraux, qui maintient une charge virale indétectable correspondant à moins de 50 copies de VIH par millilitre de sang
en elite controller 1 EC
a patient characterized by undetectable plasma viral loads for extended periods of time in the absence of ART, a subset of HIV-infected individuals who maintain plasma viral loads to levels below the limits of clinical detection (<50–75copies/ml) in the absence of anti-retroviral therapy, sujet non progresseur à long terme et séropositif non traité aux antirétroviraux, qui maintient une charge virale indétectable correspondant à moins de 50 copies de VIH par millilitre de sang

elite controller

Terminological databases

EKI terminibaas Esterm

ID 737896 Last modified 29.03.2021

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Domain immunology

elite controller

contrôleur élite

contrôleur d'élite

a patient characterized by undetectable plasma viral loads for extended periods of time in the absence of ART
a subset of HIV-infected individuals who maintain plasma viral loads to levels below the limits of clinical detection (<50–75copies/ml) in the absence of anti-retroviral therapy

sujet non progresseur à long terme et séropositif non traité aux antirétroviraux, qui maintient une charge virale indétectable correspondant à moins de 50 copies de VIH par millilitre de sang

Good to know

"Long-term non-progressor“ on laialdasemat gruppi (hinnanguliselt ligi 5% nakkuse kandjatest) haarav mõiste, kelle puhul suudab immuunsüsteem viiruskoormuse alla suruda ja madalana hoida ilma ARV-ravita. Nende seas on väiksem grupp „long-term non-progressors elite controllers“ või lihtsalt „elite controllers“ (hinnanguliselt 0,2-0,5% nakkuse kandjatest), kelle puhul on viiruskoormus alla detekteerimispiiri (enamikel testidel on see 20-40 koopiat ühe milliliitri vere kohta) ning kõrge CD4 rakkude tase (üle 500 raku mikroliitris) lausa kümneid aastaid. Lisaks on neil ka madal immuunaktivatsiooni tase, mistõttu ei teki neil HIV-infektsioonile omast immuunkurnatust. Selle tulemusena ongi neil äärmiselt aeglane haiguse progressioon.

elite controller

loanword

Good to know

Kahjuks eestikeelne termin praegu puudub. Infektsionistid kasutavad ingliskeelseid termineid. [29.03.2021]

elite controller

Usage examples

Elite controllers (ECs) are a small subset of HIV-1 infected individuals (on the order of 1 in 200 to 1 in 500 or 0.2 to 0.5 percent) who have the ability to suppress viremia to undetectable levels (< 50 copies/ml), while maintaining elevated CD4 cell counts (200 to 1000/μl) in the absence of ART. ... A similar subset of HIV-infected individuals termed viremic controllers (VCs) achieve a lesser degree of virologic control (200 < VL < 2000 copies/ml), while also maintaining elevated CD4 cell counts (typically ≤ 500/ μl), in the absence of ART. ECs and VCs are part of a significantly larger cohort of HIV-infected persons, described as long-term non-progressors (LTNP). LTNP are characterized by their ability to maintain elevated CD4 cell counts in the absence of ART.

EC abbreviation

contrôleur élite

contrôleur d'élite

in the EU's IATE term base

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elite controller

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EKI terminibaas Esterm

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