a patient characterized by undetectable plasma viral loads for extended periods of time in the absence of ART
a subset of HIV-infected individuals who maintain plasma viral loads to levels below the limits of clinical detection (<50–75copies/ml) in the absence of anti-retroviral therapy
sujet non progresseur à long terme et séropositif non traité aux antirétroviraux, qui maintient une charge virale indétectable correspondant à moins de 50 copies de VIH par millilitre de sang
Hea teada
"Long-term non-progressor“ on laialdasemat gruppi (hinnanguliselt ligi 5% nakkuse kandjatest) haarav mõiste, kelle puhul suudab immuunsüsteem viiruskoormuse alla suruda ja madalana hoida ilma ARV-ravita. Nende seas on väiksem grupp „long-term non-progressors elite controllers“ või lihtsalt „elite controllers“ (hinnanguliselt 0,2-0,5% nakkuse kandjatest), kelle puhul on viiruskoormus alla detekteerimispiiri (enamikel testidel on see 20-40 koopiat ühe milliliitri vere kohta) ning kõrge CD4 rakkude tase (üle 500 raku mikroliitris) lausa kümneid aastaid. Lisaks on neil ka madal immuunaktivatsiooni tase, mistõttu ei teki neil HIV-infektsioonile omast immuunkurnatust. Selle tulemusena ongi neil äärmiselt aeglane haiguse progressioon.
Elite controllers (ECs) are a small subset of HIV-1 infected individuals (on the order of 1 in 200 to 1 in 500 or 0.2 to 0.5 percent) who have the ability to suppress viremia to undetectable levels (< 50 copies/ml), while maintaining elevated CD4 cell counts (200 to 1000/μl) in the absence of ART. ... A similar subset of HIV-infected individuals termed viremic controllers (VCs) achieve a lesser degree of virologic control (200 < VL < 2000 copies/ml), while also maintaining elevated CD4 cell counts (typically ≤ 500/ μl), in the absence of ART. ECs and VCs are part of a significantly larger cohort of HIV-infected persons, described as long-term non-progressors (LTNP). LTNP are characterized by their ability to maintain elevated CD4 cell counts in the absence of ART.
