those where the autoantigens are found in almost any type of cell in the body, for example the DNA - protein complexes
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Autoimmune diseases are divided into two classes: organ-specific and systemic. An organ-specific disease is one in which an immune response is directed toward antigens in a single organ. Examples are Addison disease, in which autoantibodies attack the adrenal cortex, and myasthenia gravis, in which they attack neuromuscular cells. In systemic diseases the immune system attacks self antigens in several organs. Systemic lupus erythematosus, for example, is characterized by inflammation of the skin, joints, and kidneys, among other organs.
Surnud isik arvatakse rakkude ja kudede doonorlusest välja, kui lahkamine ei anna teavet surma põhjuse kohta ja surma põhjus on teadmata või kehtib üks alljärgnevatest kriteeriumitest: ... 6) kroonilise, süsteemse autoimmuunhaiguse varasem esinemine, millel võib olla kahjulik mõju võetavate rakkude, kudede või elundite kvaliteedile;
Süsteemne erütematoosluupus (SEL) on süsteemne autoimmuunhaigus, mis tabab enamasti noores eas inimesi, eelistatult naisi.
Typical systemic autoimmune diseases are rheumatoid arthritis, systemic lupus erythematosus, scleroderma, and dermatomyositis. These diseases are managed by rheumatologists, and in fact the terms "systemic autoimmune disease" and "rheumatic autoimmune diseases" are often used interchangeably.
Systemic autoimmune diseases (often referred to as “connective tissue diseases”) are a large and clinically diverse cluster of disorders.
