(normaalse) raku pärilikkusaine geen, mis võib DNA kahjustumisel muutuda pahaloomulise kasvaja tekitajaks
geen, mis soodustab ja kontrollib rakkude jagunemist, aga võib põhjustada loomarakkude kasvu täieliku peatamise või ka vohamise (kasvajaliste rakkude kasvu e. transformatsiooni) koekultuuris ja kasvajate teket in vivo
geen, mis muudab normaalse raku kasvajarakuks, proto-onkogeeni mutantne vorm
a gene that causes cells to grow in an uncontrolled (for example, tumourous) manner
a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell
any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer
a sequence of deoxyribonucleic acid (DNA) that has been altered or mutated from its original form, the proto-oncogene
gène dont le produit d'expression peut perturber le contrôle métabolique normal de la cellule, et conduit à sa cancérisation
gène induisant un fonctionnement aberrant dans une cellule qui se multiplie sans fin et forme des tumeurs malignes
Retroviral insertion can convert a proto-oncogene, integral to the control of cell division, into an oncogene, the agent responsible for transforming a healthy cell into a cancer cell.
Chromosome mutations and related events are the cause of many human genetic diseases and there is substantial evidence that chromosome mutations and related events causing alterations in oncogenes and tumour-suppressor genes of somatic cells are involved in cancer induction in humans and experimental animals.
