SCAN acknowledges the probability that resistant enterococci or erm-resistance genes will be transferred from animals to humans will be higher, the higher the prevalence of resistant enterococci in animals is.
Sites of Action: In general, antibiotics target bacterial machines of macromolecular biosynthesis. ... Protein Synthesis (Aminoglycosides, tetracycline, erythromycin, chloramphenicol). All target the ribosome. Aminoglycosides target the 30S subunit and are cidal. Tet targets the 30S subunit and is static. Erm is a macrolide that targets the 50S subunit. Can be cidal or static. ... Mechanisms of antibiotic resistance ... Acquired by genetic exchange: This is the clinically relevant form of antibiotic resistance. ... Here are some mechanisms. ... alteration of target: Erm resistance is mediated by methylation of an adenine on the 23S rRNA.
