kromosoomi esinemisest tingitud kaasasündinud sündroom, millele on iseloomulikud vaimne alaareng, holopros­entse­faalia, kükloopia, suulae- ja huulelõhe, polü­dak­tüülia ning südame, seedeelundite ja suguelundite patoloogia, a chromosomal disorder resulting in a syndrome characterized by specific (midline) dysmorphic features and organ malformations, a congenital condition that is characterized especially by usually severe mental retardation and by craniofacial, cardiac, ocular, and cerebral abnormalities, is caused by trisomy of the human chromosome numbered 13, and is typically fatal especially within the first six months of life